Structure of PDB 4lue Chain A

Receptor sequence
>4lueA (length=423) Species: 9606 (Homo sapiens) [Search protein sequence]
RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIP
SNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGS
YSLSVRDYDPRQGDTVKHYKIRTGFYISPRSTFSTLQELVDHYKKGNDGL
CQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNK
HTKVAVKTMKPGSLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKG
SLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILV
SASLVCKIADFGLARVIPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT
YGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERP
TFEYIQSVLDDFYTATESQYEEI
3D structure
PDB4lue Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
ChainA
Resolution3.04 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D292 R294 A296 N297 D310
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VSE A V281 A293 K295 V323 T338 M341 G344 D348 L393 D404 F405 V193 A205 K207 V229 T244 M247 G250 D254 L299 D310 F311 BindingDB: IC50=0.426580nM
BS02 CA A E524 Y527 E417 Y420
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4lue, PDBe:4lue, PDBj:4lue
PDBsum4lue
PubMed24531473
UniProtP08631|HCK_HUMAN Tyrosine-protein kinase HCK (Gene Name=HCK)

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