Structure of PDB 4lud Chain A

Receptor sequence
>4ludA (length=422) Species: 9606 (Homo sapiens) [Search protein sequence]
RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIP
SNYVARLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSL
SVRDYDPRQGDTVKHYKIRTLDGFYISPRSTFSTLQELVDHYKKGNDGLC
QKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKH
TKVAVKTMKPSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMA
KGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANI
LVSASLVCKIADFGLARVIPIKWTAPEAINFGSFTIKSDVWSFGILLMEI
VTYGRIPYPGMSNPELERGYRMPRPENCPEELYNIMMRCWKNRPEERPTF
EYIQSVLDDFYTATESQYEEIP
3D structure
PDB4lud Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
ChainA
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D294 R296 A298 N299 D312
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E524 Y527 E529 E415 Y418 E420
BS02 SK8 A L273 V281 K295 I336 T338 M341 L393 L184 V192 K206 I244 T246 M249 L301
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4lud, PDBe:4lud, PDBj:4lud
PDBsum4lud
PubMed24531473
UniProtP08631|HCK_HUMAN Tyrosine-protein kinase HCK (Gene Name=HCK)

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