Structure of PDB 4luc Chain A

Receptor sequence
>4lucA (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
SLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHKE
3D structure
PDB4luc K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
ChainA
Resolution1.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 20G A V9 G10 C12 G60 Q61 E62 R68 M72 Y96 Q99 I100 V9 G10 C12 G60 Q61 E62 R68 M72 Y96 Q99 I100
BS02 GDP A G13 G15 K16 S17 A18 F28 D30 N116 K117 D119 S145 A146 K147 G13 G15 K16 S17 A18 F28 D30 N116 K117 D119 S145 A146 K147
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4luc, PDBe:4luc, PDBj:4luc
PDBsum4luc
PubMed24256730
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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