Structure of PDB 4ltw Chain A

Receptor sequence

>4ltwA (length=251) [Search protein sequence]

SNAPSLISILQAIEPEVVYAGYDNTQPDTTNYLLSSLNRLAEKQLVSVVK
WAKALPGFRNLHLDDQMTLIQYSWMGLMAFAMGWRSYKHTNGQMLYFAPD
LIFNEQRMQQSAMYDLCQGMQQISQEFVRLQVTQEEFLCMKALLLLSTVP
KEGLKSQASFDEMRMNYIKELNRAIAKKENNSAQNWQRFYQLTKLLDSMH
DLVGGLLQFCFYTFVQSQALSVEFPEMLVEIISAQLPKVLAGMAKPLLFH
K

3D structure

PDB

4ltw X-ray crystal structure of the ancestral 3-ketosteroid receptor-progesterone-mifepristone complex shows mifepristone bound at the coactivator binding interface.

Chain

Resolution

2.045 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	STR	A	L34 N35 Q41 M72 M79 F206 C207	L37 N38 Q44 M75 M82 F209 C210
BS02	486	A	L42 K50 Q63 M64 I67 Q68 M224 I228	L45 K53 Q66 M67 I70 Q71 M227 I231
BS03	486	A	F206 Y209	F209 Y212

External links

PDB	RCSB:4ltw, PDBe:4ltw, PDBj:4ltw
PDBsum	4ltw
PubMed	24260475

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