Structure of PDB 4lt6 Chain A

Receptor sequence

>4lt6A (length=467) Species: 9606 (Homo sapiens)

KHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGK
LNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDAL
CVAPRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEID
LVFARLAIQTISDNLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNK
ETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAAST
LVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIIT
PAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNF
FQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVN
PQSFPGNYVSMWFLGIIFRDLTYDIQSFTDTVYRQANNINMLKEGMKIEA
THVKKKQLHHYLPAEIL

3D structure

• PDB: 4lt6 Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases.
• Chain: A
• Resolution: 2.79 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S101 D112 D114 D166 K227 Y236
• Catalytic site (residue number reindexed from 1): S85 D96 D98 D150 K211 Y220
• Enzyme Commision number: 2.7.7.19: polynucleotide adenylyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	3AT	A	F99 G100 S101 D114 K227 Y236 V246	F83 G84 S85 D98 K211 Y220 V230
BS02	CA	A	D112 D114	D96 D98

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0016779 nucleotidyltransferase activity
• GO:1990817 poly(A) RNA polymerase activity

Biological Process

• GO:0031123 RNA 3'-end processing

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:4lt6, PDBe:4lt6, PDBj:4lt6
• PDBsum: 4lt6
• PubMed: 24076191
• UniProt: Q9BWT3|PAPOG_HUMAN Poly(A) polymerase gamma (Gene Name=PAPOLG)