Structure of PDB 4lt5 Chain A

Receptor sequence
>4lt5A (length=265) Species: 5762 (Naegleria gruberi) [Search protein sequence]
INKKSLLQNLLSKCKTTFQQSFTNANITLKDEKWLKNVRTAYFVCDHDGS
VELAYLPNVLPKELVEEFTEKFESIQTGRKKDTGYSGILDNSMPFNYVTA
DLSQELGQYLSEIVNPQINYYISKLLTCVSSRTINYLVSLNDSYYALNNC
LYPSTAFNSLKPSNDGHRIRKPHKDNLDITPSSLFYFGNFQNTEGYLELT
DKNCKVFVQPGDVLFFKGNEYKHVVANITSGWRIGLVYFAHKGSKTKPYY
EDTQKNSLKIHKETK
3D structure
PDB4lt5 Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA.
ChainA
Resolution2.893 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S148 P150 N232 K318 S92 P94 N176 K262
BS02 dna A Y141 L145 N147 Y153 T155 A156 R224 D231 D234 V293 F295 H297 Q310 K311 Y85 L89 N91 Y97 T99 A100 R168 D175 D178 V237 F239 H241 Q254 K255
BS03 MN A H229 D231 H279 H173 D175 H223
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005506 iron ion binding
GO:0010385 double-stranded methylated DNA binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0070579 5-methylcytosine dioxygenase activity

View graph for
Molecular Function
External links
PDB RCSB:4lt5, PDBe:4lt5, PDBj:4lt5
PDBsum4lt5
PubMed24390346
UniProtD2W6T1|TET1_NAEGR Tet-like dioxygenase 1 (Gene Name=TET1)

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