Structure of PDB 4lsj Chain A

Receptor sequence
>4lsjA (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAV
KWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFAP
DLIINEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSV
PKDGLKSQELFDEIRMTYIKELGKAIVNWQRFYQLTKLLDSMHEVVENLL
NYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
3D structure
PDB4lsj Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 R585 L589 D590 M593 M752 E755 V50 K54 R60 L64 D65 M68 M219 E222
BS02 LSJ A L563 N564 L566 M601 M604 L608 F623 L732 Y735 C736 T739 L38 N39 L41 M76 M79 L83 F98 L199 Y202 C203 T206 MOAD: Ki=0.268nM
PDBbind-CN: -logKd/Ki=9.57,Ki=0.268nM
BindingDB: Ki=0.268000nM
External links
PDB RCSB:4lsj, PDBe:4lsj, PDBj:4lsj
PDBsum4lsj
PubMed24446728
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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