Structure of PDB 4lrh Chain A

Receptor sequence
>4lrhA (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
RTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVS
YLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERV
LNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFH
FYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFY
AAAMSGT
3D structure
PDB4lrh Structural basis for molecular recognition of folic acid by folate receptors.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FOL A Y60 D81 Y85 W102 W134 H135 K136 G137 W140 W171 S174 Y175 Y53 D74 Y78 W95 W127 H128 K129 G130 W133 W164 S167 Y168 PDBbind-CN: -logKd/Ki=9.72,Kd=0.19nM
External links
PDB RCSB:4lrh, PDBe:4lrh, PDBj:4lrh
PDBsum4lrh
PubMed23851396
UniProtP15328|FOLR1_HUMAN Folate receptor alpha (Gene Name=FOLR1)

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