Structure of PDB 4lq9 Chain A

Receptor sequence
>4lq9A (length=501) Species: 142786 (Norovirus) [Search protein sequence]
GTYCGAPILGPGSAPKLSTKTKFWRSSTTPLPPGTYEPAYLGGKDPRVKG
GPSLQQVMRDQLKPFTEPRGKPPKPSVLEAAKKTIINVLEQTIDPPEKWS
FTQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLADQASKANLMFEGGK
NMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGLMDE
LKAHCVTLPIRVGMNMNEDGPIIFERHSRYKYHYDADYSRWDSTQQRAVL
AAALEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFKISINEGLPSGVPCT
SQWNSIAHWLLTLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDP
EKLTAKLKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGK
LEQSSILRQMYWTRGPNHEDPSETMIPHSQRPIQLMSLLGEAALHGPAFY
SKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDLSTWEGDRNLAPSFVN
E
3D structure
PDB4lq9 Naphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerase.
ChainA
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 21D A Q414 W417 T418 R419 R436 Q439 Q409 W412 T413 R414 R431 Q434 PDBbind-CN: -logKd/Ki=4.85,IC50=14uM
BS02 21D A Q66 V170 K171 K174 K180 R182 Q61 V165 K166 K169 K175 R177 PDBbind-CN: -logKd/Ki=4.85,IC50=14uM
BS03 MG A D240 D344 E345 T389 D235 D339 E340 T384
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4lq9, PDBe:4lq9, PDBj:4lq9
PDBsum4lq9
PubMed24316032
UniProtQ2N379

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