Structure of PDB 4lpn Chain A

Receptor sequence
>4lpnA (length=172) Species: 8400 (Aquarana catesbeiana) [Search protein sequence]
VSQVRQNYHSDCEAAVNRMLNLELYASYTYSSMYAFFDRDDVALHNVAEF
FKEHSHEEREHAEKFMKYQNKRGGRVVLQDIKKPERDEWGNTLEAMQAAL
QLEKTVNQALLDLHKLATDKVDPHLCEFLESEYLEEQVKDIKRIGDFITN
LKRLGLPENGMGEYLFDKHSVK
3D structure
PDB4lpn D127E ion channel exit modification in ferritin nanocages entraps Fe(II) and impairs its distribution to diiron catalytic centers
ChainA
Resolution1.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.16.3.1: ferroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO A E23 E58 H61 E23 E58 H61
BS02 CO A E58 E103 Q137 E58 E103 Q137
BS03 CO A Y30 H54 E57 E58 E103 Y30 H54 E57 E58 E103
BS04 CO A E57 E136 D140 E57 E136 D140
BS05 CO A E127 E130 E127 E130
BS06 CO A E60 E63 E60 E63
Gene Ontology
Molecular Function
GO:0004322 ferroxidase activity
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006826 iron ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0006880 intracellular sequestering of iron ion
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lpn, PDBe:4lpn, PDBj:4lpn
PDBsum4lpn
PubMed
UniProtP07798|FRI2_AQUCT Ferritin, middle subunit

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