Structure of PDB 4lp0 Chain A

Receptor sequence
>4lp0A (length=192) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
QVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFGDRIDV
TINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTILHVGSSVVNALSSWL
EVEITRDGAVYKQRFENGGKPVTTLKKIGTALKSKTGTKVTFMPDATIFS
TTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYEN
3D structure
PDB4lp0 Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1YM A E55 D78 R81 M83 P84 I98 E39 D62 R65 M67 P68 I82 MOAD: ic50<10nM
PDBbind-CN: -logKd/Ki=8.00,IC50<0.01uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4lp0, PDBe:4lp0, PDBj:4lp0
PDBsum4lp0
PubMed24098982
UniProtQ8DQB5

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