Structure of PDB 4lor Chain A

Receptor sequence
>4lorA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
PTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCA
YDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSN
EERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHD
DMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVV
TLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSN
ALDIIFQTDLTGQKKGWKLRYHGDPM
3D structure
PDB4lor Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.42: complement subcomponent C1s.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E45 Y52 D98 F99 S100 E102 E44 Y51 D97 F98 S99 E101
BS02 CA A E45 D53 D98 S100 N101 E44 D52 D97 S99 N100
BS03 CA A D116 I117 E119 N134 F135 G137 G138 D115 I116 E118 N133 F134 G136 G137
BS04 CA A E211 D221 D260 T262 G263 E210 D220 D259 T261 G262
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:4lor, PDBe:4lor, PDBj:4lor
PDBsum4lor
PubMed23922389
UniProtP09871|C1S_HUMAN Complement C1s subcomponent (Gene Name=C1S)

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