Structure of PDB 4lol Chain A

Receptor sequence
>4lolA (length=178) Species: 10090 (Mus musculus) [Search protein sequence]
VAHGLAWSYYIGYLRLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPL
DGVPDNLSVVDPNIRFRDMLPQQNIDRAGIKNRVYSNSVYEILENGQPAG
VCILEYATPLQTLFAMSQDAKAGFSREDRLEQAKLFCRTLEEILEDVPES
RNNCRLIVYQEPTDSFSLSQEVLRHIRQ
3D structure
PDB4lol Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.
ChainA
Resolution2.43 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1YE A S161 G165 R237 S8 G12 R83 MOAD: Kd=0.49uM
BindingDB: Kd=130nM
BS02 1YE A S161 Y162 Y166 T262 P263 Q265 T266 S8 Y9 Y13 T108 P109 Q111 T112 MOAD: Kd=0.49uM
BindingDB: Kd=130nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4lol, PDBe:4lol, PDBj:4lol
PDBsum4lol
PubMed23910378
UniProtQ3TBT3|STING_MOUSE Stimulator of interferon genes protein (Gene Name=Sting1)

[Back to BioLiP]