Structure of PDB 4loj Chain A

Receptor sequence
>4lojA (length=180) Species: 10090 (Mus musculus) [Search protein sequence]
AHGLAWSYYIGYLRLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLD
CGVPDNLSVVDPNIRFRDMLPQQNIDRAGIKNRVYSNSVYEILENGQPAG
VCILEYATPLQTLFAMSQDAKAGFSREDRLEQAKLFCRTLEEILEDVPES
RNNCRLIVYQEPTDGNSFSLSQEVLRHIRQ
3D structure
PDB4loj Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.
ChainA
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1SY A S161 Y162 Y166 R237 Y239 T262 S7 Y8 Y12 R83 Y85 T108 PDBbind-CN: -logKd/Ki=6.52,Kd=0.3uM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4loj, PDBe:4loj, PDBj:4loj
PDBsum4loj
PubMed23910378
UniProtQ3TBT3|STING_MOUSE Stimulator of interferon genes protein (Gene Name=Sting1)

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