Structure of PDB 4loi Chain A

Receptor sequence
>4loiA (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
SVAHGLAWSYYIGYLRLILPELQARIRTYNQHRGAVSQRLYILLPLDCGV
PDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCV
LEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPQNNCR
LIAYQEPADDSSFSLSQEVLRHLRQEEK
3D structure
PDB4loi Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.
ChainA
Resolution1.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1YC A S162 Y167 R238 T263 S9 Y14 R80 T105 PDBbind-CN: -logKd/Ki=6.77,Kd=0.17uM
BindingDB: EC50=30nM,Kd=287000nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4loi, PDBe:4loi, PDBj:4loi
PDBsum4loi
PubMed23910378
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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