Structure of PDB 4lnw Chain A

Receptor sequence
>4lnwA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPD
DIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPC
EDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGV
VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA
YLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPT
ELFPPLFLEVFED
3D structure
PDB4lnw Identification of a new hormone-binding site on the surface of thyroid hormone receptor.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T3 A F215 F218 I222 R228 M256 M259 R262 L276 S277 L292 H381 F401 F71 F74 I78 R84 M112 M115 R118 L132 S133 L148 H237 F257 PDBbind-CN: -logKd/Ki=7.04,Kd=90.9nM
BS02 T3 A Q342 L368 V371 R375 Q198 L224 V227 R231 PDBbind-CN: -logKd/Ki=7.04,Kd=90.9nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4lnw, PDBe:4lnw, PDBj:4lnw
PDBsum4lnw
PubMed24552590
UniProtP10827|THA_HUMAN Thyroid hormone receptor alpha (Gene Name=THRA)

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