Structure of PDB 4lkl Chain A

Receptor sequence
>4lklA (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKY
GLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNS
LMKKITLLKYFRNYMSEHLLKAGANITPLPYLRTWFRTRSAIILHLSNGS
VQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASR
LRYARTMVDKLLSS
3D structure
PDB4lkl Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1
ChainA
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K413 W414 D416 L490 L491 R516 F535 H538 K540 K42 W43 D45 L119 L120 R137 F156 H159 K161
BS02 ADM A L491 R518 L120 R139 PDBbind-CN: -logKd/Ki=6.09,IC50=0.82uM
External links
PDB RCSB:4lkl, PDBe:4lkl, PDBj:4lkl
PDBsum4lkl
PubMed24223211
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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