Structure of PDB 4lkk Chain A

Receptor sequence
>4lkkA (length=314) Species: 11320 (Influenza A virus) [Search protein sequence]
ICLGHHAVSNGTKVNTLTERGVEVVNATETVERTNIPRICSKGKRTVDLG
QCGLLGTITGPPQCDQFLEFSADLIIERREGSDVCYPGKFVNEEALRQIL
RESGGIDKEAMGFTYSGIRTNGATSACRRSGSSFYAEMKWLLSNTDNAAF
PQMTKSYKNTRKSPALIVWGIHHSVSTAEQTKLYGSGNKLVTVGSSNYQQ
SFVPSPGARPQVNGQSGRIDFHWLMLNPNDTVTFSFNGAFIAPDRASFLR
GKSMGIQSGVQVDANCEGDCYHSGGTIISNLPFQNIDSRAVGKCPRYVKQ
RSLLLATGMKNVPE
3D structure
PDB4lkk Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses
ChainA
Resolution2.491 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL A G216 Q217 G214 Q215 PDBbind-CN: -logKd/Ki=5.92,Kd=1.20uM
BS02 SIA A Y88 A125 T126 S127 W142 H174 E181 Q217 Y86 A123 T124 S125 W140 H172 E179 Q215 PDBbind-CN: -logKd/Ki=5.92,Kd=1.20uM
Gene Ontology
Molecular Function
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046718 symbiont entry into host cell
GO:0075512 clathrin-dependent endocytosis of virus by host cell
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lkk, PDBe:4lkk, PDBj:4lkk
PDBsum4lkk
PubMed24009358
UniProtV5IRV5

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