Structure of PDB 4lk9 Chain A

Receptor sequence

>4lk9A (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]

HMLELPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHP
SCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFH
MECCDPPLTRMPKGMWICQICRPRKK

3D structure

PDB

4lk9 The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.

Chain

Resolution

1.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	F211 L242 K243 I260 E261 A275 D276 M278 L279 F280 C281 D282 D285 M300 G303	F22 L53 K54 I71 E72 A86 D87 M89 L90 F91 C92 D93 D96 M111 G114
BS02	ZN	A	C281 C284 C307 C310	C92 C95 C118 C121
BS03	ZN	A	C265 C268 H289 C292	C76 C79 H100 C103
BS04	ZN	A	C209 C212 H238 C241	C20 C23 H49 C52
BS05	ZN	A	C230 C233 C259 C262	C41 C44 C70 C73

External links

PDB	RCSB:4lk9, PDBe:4lk9, PDBj:4lk9
PDBsum	4lk9
PubMed	24150941
UniProt	Q92794\|KAT6A_HUMAN Histone acetyltransferase KAT6A (Gene Name=KAT6A)

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