Structure of PDB 4lk3 Chain A

Receptor sequence

>4lk3A (length=267) Species: 9606 (Homo sapiens)

RKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHEN
FELINHDVVEPLYIEVDQIYHLASPASYNPIKTLKTNTIGTLNMLGLAKR
VGARLLLASTSEVYEGKAVAETMCYAYMKQEGVEVRVARIFNTFGPRMHM
NDGRVVSNFILQALQGEPLTVYQTRAFQYVSDLVNGLVALMNSNVSSPVN
LGNPEEHTILEFAQLIKNLVGSGSEIQFRKPDIKKAKLMLGWEPVVPLEE
GLNKAIHYFRKELEYQA

3D structure

• PDB: 4lk3 Man o' war mutation in UDP-alpha-D-xylose synthase favors the abortive catalytic cycle and uncovers a latent potential for hexamer formation.
• Chain: A
• Resolution: 2.64 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): T202 S203 E204 K235 R272
• Catalytic site (residue number reindexed from 1): T110 S111 E112 K117 R154
• Enzyme Commision number: 4.1.1.35: UDP-glucuronate decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G95 G98 F99 V100 D119 N120 T123 G124 D144 V145 L159 S161 T178 T202 K235 I258 T261 H267	G8 G11 F12 V13 D32 N33 T36 G37 D57 V58 L72 S74 T86 T110 K117 I140 T143 H149
BS02	UDP	A	R272 V273 N276 F277 T288 Y290 R297 I331	R154 V155 N158 F159 T170 Y172 R175 I209
BS03	UGA	A	P148 L149 Y150 N185 G188 L189 R192 Y245 E249	P61 L62 Y63 N93 G96 L97 R100 Y127 E131

Gene Ontology

Molecular Function

• GO:0048040 UDP-glucuronate decarboxylase activity
• GO:0070403 NAD+ binding

Biological Process

• GO:0042732 D-xylose metabolic process

External links

• PDB: RCSB:4lk3, PDBe:4lk3, PDBj:4lk3
• PDBsum: 4lk3
• PubMed: 25521717
• UniProt: Q8NBZ7|UXS1_HUMAN UDP-glucuronic acid decarboxylase 1 (Gene Name=UXS1)