Structure of PDB 4ljp Chain A

Receptor sequence
>4ljpA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
AQGLAMYLQENGIDCPKCKFSYALARGGCMHFACTQCRHQFCSGCYNAFY
AKNKCPEPNCRVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTE
PPAGARAVPGGGCRVIEQKEVPNGLRDEACGKETPAGYAGLCQAHYKEYL
VSLINAHSLDPATLYEVEELETATERYLHVRPQPLAGEDPPAYQARLLQK
LTEEVPLGQSIPRRR
3D structure
PDB4ljp Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C871 C874 C890 C893 C15 C18 C34 C37
BS02 ZN A C898 C901 H926 C930 C42 C45 H70 C74
BS03 ZN A C911 C916 H923 H925 C55 C60 H67 H69
BS04 ZN A C969 C986 C998 H1001 C113 C130 C142 H145
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Cellular Component
GO:0071797 LUBAC complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:4ljp, PDBe:4ljp, PDBj:4ljp
PDBsum4ljp
PubMed24141947
UniProtQ96EP0|RNF31_HUMAN E3 ubiquitin-protein ligase RNF31 (Gene Name=RNF31)

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