Structure of PDB 4lhw Chain A

Receptor sequence
>4lhwA (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
DYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGK
RIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRN
IEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKAN
INVENAFFTLARDIKAKMDKK
3D structure
PDB4lhw Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB.
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q67
Catalytic site (residue number reindexed from 1) Q62
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T22 T40 T17 T35
BS02 GNP A S17 G18 V19 G20 K21 T22 C23 F33 S35 T36 F37 S39 T40 A65 G66 N121 K122 D124 S151 K153 S12 G13 V14 G15 K16 T17 C18 F28 S30 T31 F32 S34 T35 A60 G61 N116 K117 D119 S146 K148
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4lhw, PDBe:4lhw, PDBj:4lhw
PDBsum4lhw
PubMed24072714
UniProtP61006|RAB8A_HUMAN Ras-related protein Rab-8A (Gene Name=RAB8A)

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