Structure of PDB 4lh5 Chain A

Receptor sequence
>4lh5A (length=131) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTVHTDNGSNFTSTTVKAACWWAGIKQMNKELKKIIGQVRDQAEHL
KTAVQMAVFIHNKKRKYSAGERIVDIIATDI
3D structure
PDB4lh5 Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
ChainA
Resolution2.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LF0 A A169 E170 H171 T174 M178 A97 E98 H99 T102 M106 MOAD: ic50=0.23uM
PDBbind-CN: -logKd/Ki=6.70,IC50=0.20uM
BS02 MG A D64 X65 D8 X9
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:4lh5, PDBe:4lh5, PDBj:4lh5
PDBsum4lh5
PubMed24261564
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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