Structure of PDB 4lge Chain A

Receptor sequence
>4lgeA (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
ISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCD
GGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY
3D structure
PDB4lge Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C300 C303 H320 C327 C46 C49 H66 C73
BS02 1Y0 A D297 G306 L307 R308 C309 W310 E311 D314 E319 W323 D43 G52 L53 R54 C55 W56 E57 D60 E65 W69 MOAD: ic50=3.5nM
PDBbind-CN: -logKd/Ki=8.46,IC50=3.5nM
External links
PDB RCSB:4lge, PDBe:4lge, PDBj:4lge
PDBsum4lge
PubMed23928071
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

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