Structure of PDB 4ley Chain A

Receptor sequence
>4leyA (length=359) Species: 10090 (Mus musculus) [Search protein sequence]
KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPL
SHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLI
RNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLV
PKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECL
KLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSC
FDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERN
NGFPIFDKL
3D structure
PDB4ley Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R158 L159 K160 R161 H203 E386 K395 R10 L11 K12 R13 H55 E238 K247
BS02 dna A R161 S165 A168 N196 Y200 Y201 K372 R13 S17 A20 N48 Y52 Y53 K224
BS03 dna A T334 K335 T338 T186 K187 T190
BS04 dna A R222 K315 R74 K167
BS05 ZN A H378 C385 C392 H230 C237 C244
External links
PDB RCSB:4ley, PDBe:4ley, PDBj:4ley
PDBsum4ley
PubMed24332030
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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