Structure of PDB 4lce Chain A

Receptor sequence
>4lceA (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
MPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMY
HTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVE
ETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGET
LGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDL
LFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALA
QALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIE
MREEAAREIRRAITGRIPDSLKNCVNK
3D structure
PDB4lce Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
ChainA
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S124 R266 D290 E295 H315
Catalytic site (residue number reindexed from 1) S98 R240 D264 E269 H289
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A S100 T128 G181 G183 R184 V185 Y203 D204 P205 Y206 H236 C237 N240 N243 T264 A265 R266 W318 S74 T102 G155 G157 R158 V159 Y177 D178 P179 Y180 H210 C211 N214 N217 T238 A239 R240 W292
BS02 KMT A R97 G99 S100 G101 R266 H315 W318 R71 G73 S74 G75 R240 H289 W292 BindingDB: Kd=1.260e+6nM
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:4lce, PDBe:4lce, PDBj:4lce
PDBsum4lce
PubMed24657618
UniProtQ13363|CTBP1_HUMAN C-terminal-binding protein 1 (Gene Name=CTBP1)

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