Structure of PDB 4lc9 Chain A

Receptor sequence
>4lc9A (length=567) Species: 10116 (Rattus norvegicus) [Search protein sequence]
YQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVKLLGQC
DAEIFQEEGQIVPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSG
GGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREQTEDSA
LHGIEELKKVAAGKKRVVVIGISVGLSAPFVAGQMDYCMDNTAVFLPVLV
GFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSG
SSRMKGGGATKILLETLLLAAHKTVVSSQRCLLEILRTFERAHQVTYSQS
SKIATLMKQVGISLEKKGRVHLVGWQTLGIIAIMDGVECIHTFGADFQDI
RGFLIGDTSILPSLTETDTVVFIFTLDDNLTEVQALAERVRCQNIQALVH
STVGQSLPAPLKKLFPSLISITWPLLFFDYEGTYVQKFQRELSTKWVLNT
VSTGAHVLLGKILQNHMLDLRIANSKLFWRALAMLQRFSGQSKARCIESL
LQAIHFPQPLSDDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSISEAK
ARLSAASSVCEVVRSAL
3D structure
PDB4lc9 Structural basis for regulation of human glucokinase by glucokinase regulatory protein.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F6P A G108 T109 E150 S179 V180 G181 S258 K514 G102 T103 E144 S173 V174 G175 S252 K476
Gene Ontology
Molecular Function
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0019210 kinase inhibitor activity
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019904 protein domain specific binding
GO:0030246 carbohydrate binding
GO:0070095 fructose-6-phosphate binding
GO:0097367 carbohydrate derivative binding
GO:0141089 glucose sensor activity
Biological Process
GO:0001678 intracellular glucose homeostasis
GO:0006006 glucose metabolic process
GO:0006606 protein import into nucleus
GO:0009749 response to glucose
GO:0009750 response to fructose
GO:0033133 positive regulation of glucokinase activity
GO:0034504 protein localization to nucleus
GO:0042593 glucose homeostasis
GO:0046415 urate metabolic process
GO:0070328 triglyceride homeostasis
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lc9, PDBe:4lc9, PDBj:4lc9
PDBsum4lc9
PubMed23957911
UniProtQ07071|GCKR_RAT Glucokinase regulatory protein (Gene Name=Gckr)

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