Structure of PDB 4lay Chain A

Receptor sequence
>4layA (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
GVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSL
DRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPK
IPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVE
VALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYL
KPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKA
3D structure
PDB4lay Crystal Structures of the Free and Ligand-Bound FK1-FK2 Domain Segment of FKBP52 Reveal a Flexible Inter-Domain Hinge.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y57 F67 D68 I87 Y113 F130
Catalytic site (residue number reindexed from 1) Y36 F46 D47 I66 Y92 F109
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I63 A Y57 F67 D68 F77 G84 E85 V86 I87 W90 Y113 I122 Y36 F46 D47 F56 G63 E64 V65 I66 W69 Y92 I101 BindingDB: IC50=9370nM
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:4lay, PDBe:4lay, PDBj:4lay
PDBsum4lay
PubMed23933011
UniProtQ02790|FKBP4_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP4 (Gene Name=FKBP4)

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