Structure of PDB 4la7 Chain A

Receptor sequence
>4la7A (length=176) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
TDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNP
ERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVL
SFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEE
DTKMFVDTVVKLNLQKLGVAATSAPM
3D structure
PDB4la7 Activation of dimeric ABA receptors elicits guard cell closure, ABA-regulated gene expression, and drought tolerance.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1O A P60 K64 V85 S96 E98 F112 L121 Y124 F165 P50 K54 V75 S86 E88 F102 L111 Y114 F155 MOAD: ic50=267nM
PDBbind-CN: -logKd/Ki=6.57,IC50=267nM
Gene Ontology
Molecular Function
GO:0004864 protein phosphatase inhibitor activity
GO:0005515 protein binding
GO:0010427 abscisic acid binding
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0009738 abscisic acid-activated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0062049 protein phosphatase inhibitor complex

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Biological Process
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Cellular Component
External links
PDB RCSB:4la7, PDBe:4la7, PDBj:4la7
PDBsum4la7
PubMed23818638
UniProtO80992|PYL2_ARATH Abscisic acid receptor PYL2 (Gene Name=PYL2)

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