Structure of PDB 4l9s Chain A

Receptor sequence
>4l9sA (length=159) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSD
DVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFY
TLVREIRQH
3D structure
PDB4l9s K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
ChainA
Resolution1.606 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 G13 G15 K16 S17 A18 F28 D30 N109 K110 D112 L113 S138 A139
BS02 CA A R102 D105 R95 D98
BS03 CA A V103 D105 V96 D98
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4l9s, PDBe:4l9s, PDBj:4l9s
PDBsum4l9s
PubMed24256730
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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