Structure of PDB 4l98 Chain A

Receptor sequence
>4l98A (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIEVAIRIFQ
GCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASL
MNKDGVLISEGQGFMTREFLKSLRKPLGDFMEPKFEFAVKFNALELDDSD
LAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFA
KLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
3D structure
PDB4l98 Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy.
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LRG A F282 C285 S289 H323 Y327 H449 L465 H466 P467 Q470 F49 C52 S56 H90 Y94 H216 L232 H233 P234 Q237 BindingDB: EC50=550nM
BS02 LRG A Y473 Y477 Y240 Y244 BindingDB: EC50=550nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4l98, PDBe:4l98, PDBj:4l98
PDBsum4l98
PubMed25004973
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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