Structure of PDB 4l7n Chain A

Receptor sequence
>4l7nA (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
MKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQI
ARGFEALEALEEALKDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELL
QAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLL
DSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNR
KLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGM
KCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDP
TQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLL
EVH
3D structure
PDB4l7n Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S422 Y425 E514
Catalytic site (residue number reindexed from 1) S243 Y246 E335
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1VB A D284 L287 D291 H384 G385 R400 M402 Y414 S422 Y425 E514 D105 L108 D112 H205 G206 R221 M223 Y235 S243 Y246 E335 PDBbind-CN: -logKd/Ki=4.84,IC50=14.4uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4l7n, PDBe:4l7n, PDBj:4l7n
PDBsum4l7n
PubMed24188023
UniProtQ9Y6F1|PARP3_HUMAN Protein mono-ADP-ribosyltransferase PARP3 (Gene Name=PARP3)

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