Structure of PDB 4l7l Chain A

Receptor sequence
>4l7lA (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
MKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQI
ARGFEALEALEEALKDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELL
QAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLL
DSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNR
KLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGM
KCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDP
TQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLL
EVH
3D structure
PDB4l7l Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S422 Y425 E514
Catalytic site (residue number reindexed from 1) S243 Y246 E335
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1VA A D284 H384 G385 Y414 F415 S422 Y425 E514 D105 H205 G206 Y235 F236 S243 Y246 E335 PDBbind-CN: -logKd/Ki=6.00,IC50=1uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4l7l, PDBe:4l7l, PDBj:4l7l
PDBsum4l7l
PubMed24188023
UniProtQ9Y6F1|PARP3_HUMAN Protein mono-ADP-ribosyltransferase PARP3 (Gene Name=PARP3)

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