Structure of PDB 4l7f Chain A

Receptor sequence
>4l7fA (length=354) Species: 9606 (Homo sapiens) [Search protein sequence]
SLDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAI
KKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDV
YIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKP
SNIVVKSDCTLKILDFGLVVTRYYRAPEVILGMGYKENVDLWSVGCIMGE
MVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYA
GYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQ
HPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDWRKGI
ITIT
3D structure
PDB4l7f Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D147 K149 N152 D165 T171
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1V5 A I32 Q37 G38 V40 A53 K55 L57 M111 A113 N114 Q117 V158 L168 I28 Q33 G34 V36 A49 K51 L53 M107 A109 N110 Q113 V154 L164 MOAD: ic50=160nM
PDBbind-CN: -logKd/Ki=6.80,IC50=0.16uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4l7f, PDBe:4l7f, PDBj:4l7f
PDBsum4l7f
PubMed23916259
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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