Structure of PDB 4l7d Chain A

Receptor sequence
>4l7dA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
RLIYTAGGYFRQSLSYLEAYNPSDGTWLDLADLQVPRSGLAGCVVGGLLY
AVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHI
YAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV
GGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY
DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGH
TFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTLE
3D structure
PDB4l7d Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1VX A Y334 N414 R415 G509 A556 Y572 F577 S602 Y9 N89 R90 G184 A231 Y247 F252 S277 MOAD: ic50=0.75uM
PDBbind-CN: -logKd/Ki=6.12,IC50=0.75uM
BindingDB: IC50=750nM
External links
PDB RCSB:4l7d, PDBe:4l7d, PDBj:4l7d
PDBsum4l7d
PubMed24504667
UniProtQ14145|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Gene Name=KEAP1)

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