Structure of PDB 4l65 Chain A

Receptor sequence
>4l65A (length=750) Species: 237561 (Candida albicans SC5314) [Search protein sequence]
MVQSSVLGFPRIGGQRELKKITEAYWSGKATVEELLAKGKELREHNWKLQ
QKAGVDIIPSNDFSYYDQVLDLSLLFNAIPERYTKFDLAPIDVLFAMGRG
LQVTALEMVKWFDSNYHYVRPTFSHSTEFKLNTAAGIKPVDEFNEAKALG
VQTRPVILGPVSYLYLGKADKDSLDLEPISLLPKILPVYKELLQKLKEAG
AEQVQIDEPVLVLDLPEAVQSKFKEAYDALVGADVPELILTTYFGDVRPN
LKAIENLPVAGFHFDFVRVPEQLDEVASILKDGQTLSAGVVDGRNIWKTD
FAKASAVVQKAIEKVGKDKVVVATSSSLLHTPVDLESETKLDAVIKDWFS
FATQKLDEVVVIAKNVSGEDVSKQLEANAASIKARSESSITNDPKVQERL
TTINEALATRKAAFPERLTEQKAKYNLPLFPTTTIGSFPQTKDIRINRNK
FAKGQITAEEYEAFINKEIETVVRFQEEIGLDVLVHGEPERNDMVQYFGE
QLNGFAFTTNGWVQSYGSRYVRPPIIVGDVSRPKAMTVKESVYAQSITSK
PMKGMLTGPVTILRWSFPRDDVSGKIQALQLGLALRDEVNDLEGAGITVI
QVDEPAIREGLPLRAGKERSDYLNWAAQSFRVATSGVENSTQIHSHFCYS
DLDPNHIKALDADVVSIEFSNYIQEFSEYPNHIGLGLFDIHSPRIPSKQE
FVSRIEEILKYPASKFWVNPDCGLKTRGWPEVKESLTNMVEAAKEFRAKY
3D structure
PDB4l65 Structural analysis of a fungal methionine synthase with substrates and inhibitors.
ChainA
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.14: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H657 C659 C739 H646 C648 C722
BS02 C2F A K19 N126 D504 Y527 R530 Y531 V532 W576 K19 N115 D493 Y516 R519 Y520 V521 W565
BS03 MET A I446 G447 S448 E499 M505 M566 D614 H657 C739 G740 I435 G436 S437 E488 M494 M555 D603 H646 C722 G723
Gene Ontology
Molecular Function
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006555 methionine metabolic process
GO:0006696 ergosterol biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0019280 L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine
GO:0032259 methylation
GO:0034605 cellular response to heat
GO:0052553 symbiont-mediated perturbation of host immune response
GO:0071266 'de novo' L-methionine biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0009277 fungal-type cell wall
GO:0009986 cell surface
GO:0030446 hyphal cell wall
GO:0062040 fungal biofilm matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4l65, PDBe:4l65, PDBj:4l65
PDBsum4l65
PubMed24524835
UniProtP82610|METE_CANAL 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (Gene Name=MET6)

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