Structure of PDB 4l61 Chain A

Receptor sequence
>4l61A (length=755) Species: 237561 (Candida albicans SC5314) [Search protein sequence]
MVQSSVLGFPRIGGQRELKKITEAYWSGKATVEELLAKGKELREHNWKLQ
QKAGVDIIPSNDFSYYDQVLDLSLLFNAIPERYTKFDLAPIDVLFAMGRG
LQAAVTALEMVKWFDSNYHYVRPTFSHSTEFKLNTAAGIKPVDEFNEAKA
LGVQTRPVILGPVSYLYLGKADKDSLDLEPISLLPKILPVYKELLQKLKE
AGAEQVQIDEPVLVLDLPEAVQSKFKEAYDALVGADVPELILTTYFGDVR
PNLKAIENLPVAGFHFDFVRVPEQLDEVASILKDGQTLSAGVVDGRNIWK
TDFAKASAVVQKAIEKVGKDKVVVATSSSLLHTPVDLESETKLDAVIKDW
FSFATQKLDEVVVIAKNVSGEDVSKQLEANAASIKARSESSITNDPKVQE
RLTTINEALATRKAAFPERLTEQKAKYNLPLFPTTTIGSFPQTKDIRINR
NKFAGQITAEEYEAFINKEIETVVRFQEEIGLDVLVHGEPERNDMVQYFG
EQLNGFAFTTNGWVQSYGSRYVRPPIIVGDVSRPKAMTVKESVYAQSITS
KPMKGMLTGPVTILRWSFPRDDVSGKIQALQLGLALRDEVNDLEGAGITV
IQVDEPAIREGLPLRAGKERSDYLNWAAQSFRVATSGVENSTQIHSHFCY
SDLDPNHIKALDADVVSIEFSKKDPNYIQEFSEYPNHIGLGLFDIHSPRI
PSKQEFVSRIEEILKVYPASKFWVNPDCGLKTRGWPEVKESLTNMVEAAK
EFRAK
3D structure
PDB4l61 Structural analysis of a fungal methionine synthase with substrates and inhibitors.
ChainA
Resolution2.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.14: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MET A I446 G447 S448 E499 M505 D614 C659 C739 G740 I437 G438 S439 E489 M495 D604 C649 C728 G729
BS02 ZN A H657 C659 C739 H647 C649 C728
Gene Ontology
Molecular Function
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006555 methionine metabolic process
GO:0006696 ergosterol biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0019280 L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine
GO:0032259 methylation
GO:0034605 cellular response to heat
GO:0052553 symbiont-mediated perturbation of host immune response
GO:0071266 'de novo' L-methionine biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0009277 fungal-type cell wall
GO:0009986 cell surface
GO:0030446 hyphal cell wall
GO:0062040 fungal biofilm matrix

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4l61, PDBe:4l61, PDBj:4l61
PDBsum4l61
PubMed24524835
UniProtP82610|METE_CANAL 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (Gene Name=MET6)

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