Structure of PDB 4l46 Chain A

Receptor sequence
>4l46A (length=318) Species: 9606 (Homo sapiens) [Search protein sequence]
NRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAM
IVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGE
LFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQ
GHVKLTDFGLCKESIHDHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALM
YDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAA
SRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLEEDVSQFDSKF
TRQTPVQVFLGFTYVAPS
3D structure
PDB4l46 Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif
ChainA
Resolution3.01 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D195 K197 E199 N200 D213 T233
Catalytic site (residue number reindexed from 1) D139 K141 E143 N144 D157 T173
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5FI A Y79 G80 V82 A98 L102 Y151 L152 M202 T212 K218 F359 Y23 G24 V26 A42 L46 Y95 L96 M146 T156 K162 F296 BindingDB: Ki=20nM,IC50=160nM
BS02 ZN A H222 H228 C231 H166 H168 C171
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4l46, PDBe:4l46, PDBj:4l46
PDBsum4l46
PubMed23731517
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

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