Structure of PDB 4l42 Chain A

Receptor sequence
>4l42A (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
EKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRN
AKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQ
LEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVK
LTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALM
YDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAA
SRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKEMFRDFEYIADW
3D structure
PDB4l42 Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D195 K197 E199 N200 D213 T233
Catalytic site (residue number reindexed from 1) D135 K137 E139 N140 D153 T173
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5FI A G77 Y79 G80 L102 Y151 L152 K218 G17 Y19 G20 L42 Y91 L92 K158 BindingDB: Ki=20nM,IC50=160nM
BS02 ZN A C217 H222 H228 C231 C157 H162 H168 C171
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4l42, PDBe:4l42, PDBj:4l42
PDBsum4l42
PubMed23731517
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

[Back to BioLiP]