Structure of PDB 4l3l Chain A

Receptor sequence
>4l3lA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNA
KDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQL
EREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKL
TDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMY
DMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAAS
RLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQS
3D structure
PDB4l3l Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D195 K197 E199 N200 D213 T233
Catalytic site (residue number reindexed from 1) D134 K136 E138 N139 D152 T172
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5FI A K76 G77 Y79 G80 V82 A98 L102 L152 M202 K218 K15 G16 Y18 G19 V21 A37 L41 L91 M141 K157 BindingDB: Ki=20nM,IC50=160nM
BS02 ZN A C217 H222 H228 C231 C156 H161 H167 C170
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4l3l, PDBe:4l3l, PDBj:4l3l
PDBsum4l3l
PubMed23731517
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

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