Structure of PDB 4l29 Chain A

Receptor sequence

>4l29A (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]

GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAP
WIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYG
CDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAA
HVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT
LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP
SGQEQRYTCHVQHEGLPKPLTLRWEP

3D structure

PDB

4l29 Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.

Chain

Resolution

3.09 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y7 E63 K66 V67 H70 T73 H74 D77 Y84 R97 Y99 Y116 T143 K146 W147 Y159 T163 W167 Y171	Y7 E63 K66 V67 H70 T73 H74 D77 Y84 R97 Y99 Y116 T143 K146 W147 Y159 T163 W167 Y171
BS02	peptide	A	H191 S195 E198 S251 E254 Q255 W274 E275	H191 S195 E198 S251 E254 Q255 W274 E275

External links

PDB	RCSB:4l29, PDBe:4l29, PDBj:4l29
PDBsum	4l29
PubMed	24338476
UniProt	P04439\|HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (Gene Name=HLA-A)

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