Structure of PDB 4l0o Chain A

Receptor sequence
>4l0oA (length=363) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNP
TRFALEELIADLEGGVKGFAFASGLAGIHAVFSLLQSGDHVLLGDDVYGG
TFRLFNQVLVKNGLSCTIIDTSDISQIKKAIKPNTKALYLETPSNPLLKI
TDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVAHSGTKYLGGH
SDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRME
AHQKNALCVAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRGFSGMLSFT
LKNDSEAVAFVESLKLFILGESLGGVESLVGIPAFMTGLVRLSVGIEHEQ
DLLEDLEQAFAKI
3D structure
PDB4l0o Structure determination of cystathionine gamma-synthase from Helicobacter pylori
ChainA
Resolution2.76 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R46 Y98 D170 K195
Catalytic site (residue number reindexed from 1) R46 Y98 D170 K195
Enzyme Commision number 2.5.1.48: cystathionine gamma-synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A G74 Y98 D170 T172 S192 T194 K195 G74 Y98 D170 T172 S192 T194 K195
BS02 PLP A Y44 R46 Y44 R46
Gene Ontology
Molecular Function
GO:0003962 cystathionine gamma-synthase activity
GO:0004123 cystathionine gamma-lyase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009086 methionine biosynthetic process
GO:0019343 cysteine biosynthetic process via cystathionine
GO:0019346 transsulfuration
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4l0o, PDBe:4l0o, PDBj:4l0o
PDBsum4l0o
PubMed
UniProtP56069|METB_HELPY Cystathionine gamma-synthase (Gene Name=metB)

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