Structure of PDB 4l0l Chain A

Receptor sequence
>4l0lA (length=501) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
VRHIAIPAHRGLITDRNGEPLAVSTPVTTLWANPKELMTAKERWPQLAAA
LGQDTKLFADRIEQNAEREFIYLVRGLTPEQGEGVIALKVPGVYSIEEFR
RFYPAGEVVAHAVGFTDVDDRGREGIELAFDEWLAGVPGKRQVLKDRRGR
VIKDVQVTKNAKPGKTLALSIDLRLQYLAHRELRNALLENGAKAGSLVIM
DVKTGEILAMTNQPTYNPNNRRNLQPAAMRNRAMIDVFEPGSTVKPFSMS
AALASGRWKPSDIVDVYPGTLQIGRYTIRDVSRNSRQLDLTGILIKSSNV
GISKIAFDIGAESIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKAET
ATLAYGYGLSVTAIQLAHAYAALANDGKSVPLSMTRVDRVPDGVQVISPE
VASTVQGMLQQVVEAQGGVFRAQVPGYHAAGKSGTARKNAYRSLFAGFAP
ATDPRIAMVVVIDEPSKAGYFGGLVSAPVFSKVMAGALRLMNVPPDNLPT
A
3D structure
PDB4l0l Pyridone-conjugated monobactam antibiotics with gram-negative activity.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PFV A E291 S294 V333 S349 N351 Y409 S485 G486 T487 A488 R489 Y503 F533 E239 S242 V281 S297 N299 Y357 S433 G434 T435 A436 R437 Y441 F471 PDBbind-CN: -logKd/Ki=7.27,IC50=54nM
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0008658 penicillin binding
GO:0008955 peptidoglycan glycosyltransferase activity
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
GO:0016757 glycosyltransferase activity
Biological Process
GO:0000917 division septum assembly
GO:0006508 proteolysis
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0043093 FtsZ-dependent cytokinesis
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4l0l, PDBe:4l0l, PDBj:4l0l
PDBsum4l0l
PubMed23755848
UniProtQ51504

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