Structure of PDB 4kyt Chain A

Receptor sequence
>4kytA (length=975) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEESLWEL
VIEQFEDLLVRILLLAACISFVLAWFETAFVEPFVILLILIANAIVGVWQ
ERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDK
VPADIRILSIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNML
FSGTNIAAGKALGIVATTGVSTEIGKIRDQMAADKTPLQQKLDEFGEQLS
KVISLICVAVWLINIGHFNDPIRGAIYYFKIAVALAVAAIPEGLPAVITT
CLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMF
IIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDKPIRSGQFDGLVELATIC
ALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRNLSKVER
ANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGA
PEGVIDRCNYVRVGTTRVPMTGPVKEKILSVIKEWGTGRDTLRCLALATR
DTPPKREEMVLDDSSRFMEYETDLTFVGVVGMLDPPRKEVMGSIQLCRDA
GIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQR
EACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIG
IAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISS
NVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIM
DRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFMYAEDGPGVTY
HQLTHFMQCTEDHPHFEGLDCEIFEAPEPMTMALSVLVTIEMCNALNSLS
ENQSLMRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLKALDLTQW
LMVLKISLPVIGLDEILKFIARNYL
3D structure
PDB4kyt The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum.
ChainA
Resolution2.833 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D351 D703 D707
Catalytic site (residue number reindexed from 1) D334 D686 D690
Enzyme Commision number 7.2.2.10: P-type Ca(2+) transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L96 I97 W107 Q108 W794 G801 T805 F809 W932 L939 L943 L88 I89 W99 Q100 W777 G784 T788 F792 W915 L922 L926
BS02 GLC A F455 L478 F438 L461
BS03 GLC A F455 N456 T457 F438 N439 T440
BS04 GLC A K511 R529 T532 T533 R534 K494 R512 T515 T516 R517
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005388 P-type calcium transporter activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction
GO:0070588 calcium ion transmembrane transport
GO:0106134 positive regulation of cardiac muscle cell contraction
GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum
GO:1990036 calcium ion import into sarcoplasmic reticulum
Cellular Component
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4kyt, PDBe:4kyt, PDBj:4kyt
PDBsum4kyt
PubMed23996003
UniProtP04191|AT2A1_RABIT Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Gene Name=ATP2A1)

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