Structure of PDB 4kxq Chain A

Receptor sequence

>4kxqA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]

HMRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYA
RLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIA
LSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCE
AVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKD
EVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGD
CDVIINELCHRLGGEYAKLCCNPVKLSEI

3D structure

PDB

4kxq Structural and Functional Analysis of Human SIRT1.

Chain

Resolution

1.849 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	P271 D272 F273 R274 N346 D348 H363
Catalytic site (residue number reindexed from 1)	P40 D41 F42 R43 N115 D117 H132
Enzyme Commision number	2.3.1.- 2.3.1.286: protein acetyllysine N-acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	K236 N241 T242 I243 R276 R466 P468 D475 E477 L479 G480 D481 I485	K5 N10 T11 I12 R45 R235 P237 D244 E246 L248 G249 D250 I254
BS02	ZN	A	C371 C374 C395 C398	C140 C143 C164 C167
BS03	APR	A	G261 G263 V266 D272 F273 R274 Y280 Q345 H363 G440 S441 S442 V445 N465 R466 E467 D481 C482	G30 G32 V35 D41 F42 R43 Y49 Q114 H132 G209 S210 S211 V214 N234 R235 E236 D250 C251

Gene Ontology

	Molecular Function
GO:0070403	NAD+ binding

View graph for
Molecular Function

External links

PDB	RCSB:4kxq, PDBe:4kxq, PDBj:4kxq
PDBsum	4kxq
PubMed	24120939
UniProt	Q96EB6\|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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