Structure of PDB 4kxl Chain A

Receptor sequence
>4kxlA (length=135) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RRSVYFCGSIRGGREDQALYARIVSRLRRYGKVLTEHVAEAAGGDQFIHE
QNLNWLQQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRPQSGRVLS
AMIRGAADGSRFQVWDYAEGEVETMLDRYFEAYLV
3D structure
PDB4kxl N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1.
ChainA
Resolution1.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6C6 A C15 G16 S17 I18 R19 H45 V46 I65 N69 S87 G89 E93 C7 G8 S9 I10 R11 H37 V38 I48 N52 S70 G72 E76 MOAD: Kd=0.6uM
PDBbind-CN: -logKd/Ki=6.22,Kd=0.6uM
BS02 6C6 A S117 M119 S100 M102 MOAD: Kd=0.6uM
PDBbind-CN: -logKd/Ki=6.22,Kd=0.6uM
Gene Ontology
Molecular Function
GO:0070694 deoxyribonucleoside 5'-monophosphate N-glycosidase activity
Biological Process
GO:0009159 deoxyribonucleoside monophosphate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4kxl, PDBe:4kxl, PDBj:4kxl
PDBsum4kxl
PubMed24260472
UniProtO35820|DNPH1_RAT 5-hydroxymethyl-dUMP N-hydrolase (Gene Name=Dnph1)

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