Structure of PDB 4kvd Chain A

Receptor sequence
>4kvdA (length=304) Species: 33178 (Aspergillus terreus) [Search protein sequence]
LEPPPSTFQPLCHPLVEEVSKEVDGYFLQHWNFPNEKARKKFVAAGFSRV
TCLYFPKALDDRIHFACRLLTVLFLIDDLLEYMSFEEGSAYNEKLIPISR
GDVLPDRSIPVEYIIYDLWESMRAHDREMADEILEPVFLFMRAQTDRTRA
RPMGLGGYLEYRERDVGKELLAALMRFSMGLKLSPSELQRVREIDANCSK
HLSVVNDIYSYEKELYTSKTAHSEGGILCTSVQILAQEADVTAEAAKRVL
FVMCREWELRHQLLVARLSAEGLETPGLAAYVEGLEYQMSGNELWSQTTL
RYSV
3D structure
PDB4kvd Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y61 F81 F147 K175 W302
Catalytic site (residue number reindexed from 1) Y54 F74 F140 K168 W295
Enzyme Commision number 4.2.3.9: aristolochene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 POP A D84 R169 N213 S217 E221 R308 Y309 D77 R162 N206 S210 E214 R301 Y302
BS02 MG A N213 S217 E221 N206 S210 E214
BS03 1SS A L77 L80 F81 F147 V173 N213 L70 L73 F74 F140 V166 N206
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0045483 aristolochene synthase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4kvd, PDBe:4kvd, PDBj:4kvd
PDBsum4kvd
PubMed23905850
UniProtQ9UR08|ARIS_ASPTE Aristolochene synthase (Gene Name=Ari1)

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