Structure of PDB 4ku8 Chain A

Receptor sequence
>4ku8A (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
GSTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQ
GARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVR
TANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF
3D structure
PDB4ku8 Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I.
ChainA
Resolution1.994 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLY A E226 E229 F230 E10 E13 F14
BS02 GLY A V346 A350 V130 A134
BS03 GLY A G217 S218 L221 G1 S2 L5
Gene Ontology
Molecular Function
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4ku8, PDBe:4ku8, PDBj:4ku8
PDBsum4ku8
PubMed24239458
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

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