Structure of PDB 4ku7 Chain A

Receptor sequence
>4ku7A (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
KHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDT
FFIISKGTVNVTREDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVT
CLVIDRDSFKHLIGGLDDVSNKAY
3D structure
PDB4ku7 Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I.
ChainA
Resolution1.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PCG A V283 L296 R297 F305 G306 E307 K308 A309 R316 T317 Y351 V61 L69 R70 F78 G79 E80 K81 A82 R89 T90 Y124 MOAD: Kd=12nM
Gene Ontology
Molecular Function
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4ku7, PDBe:4ku7, PDBj:4ku7
PDBsum4ku7
PubMed24239458
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

[Back to BioLiP]