Structure of PDB 4kto Chain A

Receptor sequence
>4ktoA (length=377) Species: 266834 (Sinorhizobium meliloti 1021) [Search protein sequence]
MFEAGLNFALGEEIDALRASVRRFASERIAPLADDADRSNAFPMSLWREM
GELGLLGITADEAHGGAGLGYLAHCVAMEEISRASASVGLSYGAHSNLCV
NQINRNGKPAQKSRYLPKLISGEHVGALAMSEPGVSMKLKADKRGDRYVL
NGSKMWITNGPDADVLVVYAKTDPPRGITAFLVEKAFPGFSAGQKLDKLG
MRGSNTSELIFTDCEVPEENVLGGVGEGVKVLMSGLDYERVVLSAGPLGI
MAACLDVVVPYLHERKQFGQPIGEFQLMQGKLADMYVTMNAARAYVYAVA
AACDRGETARKDAAGCILYAAEKATAMALEAIQALGGNGYTNDYPAGRLL
RDAKLYEIGAGTSEIRRMLIGRELFAE
3D structure
PDB4kto Crystal structure of a Putative Isovaleryl-CoA dehydrogenase from Sinorhizobium meliloti 1021
ChainA
Resolution2.137 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) M130 S131 E247 A368 R380
Catalytic site (residue number reindexed from 1) M130 S131 E239 A360 R372
Enzyme Commision number 1.3.8.4: isovaleryl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A L128 M130 S131 M160 W161 T163 L363 G367 T370 E372 L128 M130 S131 M155 W156 T158 L355 G359 T362 E364
BS02 FAD A R273 F276 I280 F283 M286 Q341 A342 G345 R265 F268 I272 F275 M278 Q333 A334 G337
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003995 acyl-CoA dehydrogenase activity
GO:0008470 3-methylbutanoyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006552 L-leucine catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4kto, PDBe:4kto, PDBj:4kto
PDBsum4kto
PubMed
UniProtQ92VK1

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